321 Lowering the intracellular antioxidant system triggers impaired barrier function
نویسندگان
چکیده
منابع مشابه
The Role of Impaired Epidermal Barrier Function in Atopic Dermatitis.
Atopic dermatitis (AD) is a chronic, inflammatory, pruritic skin disease with increasing prevalence. The etiopathogenesis of atopic dermatitis is multifactorial and involves a complex interplay of environmental and genetic factors that induce derangements in the structure and function of the epidermal barrier and immune system. Due to great heterogeneity of etiopathogenesis, there is also great...
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Crowdsensing has the potential to support human-driven sensing and data collection at an unprecedented scale. While many organizers of data collection campaigns may have extensive domain knowledge, they do not necessarily have the skills required to develop robust software for crowdsensing. In this paper, we present Mobile Campaign Designer, a tool that simplifies the creation of mobile crowdse...
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The skin provides an efficient permeability barrier and protects from microbial invasion and oxidative stress. Here, we show that these essential functions are linked through the Nrf2 transcription factor. To test the hypothesis that activation of Nrf2 provides skin protection under stress conditions, we determined the consequences of pharmacological or genetic activation of Nrf2 in keratinocyt...
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The objective of this experiment was to investigate the influence of weaning stress and an antioxidant blend on gut health and free radical metabolism in postweaning pigs. A total of 96 pigs from 12 litters were randomly divided by litter to 3 groups with 4 litters each. The control group and the weaning group were fed the basal diet, and the antioxidant group was fed the basal diet supplemente...
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Despite a drastic increase in available Open and Linked Data, unmediated utilization of these data by end users is still relatively uncommon. Applications built on top of Open Data are typically domainspecific and discovering appropriate solutions that fit users’ rapidly shifting needs is a cumbersome process. In line with the Linked Data paradigm, end user tools should be based on openness, fo...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2019
ISSN: 0022-202X
DOI: 10.1016/j.jid.2019.03.397